1yfe: Difference between revisions

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[[Image:1yfe.gif|left|200px]]
{{Seed}}
[[Image:1yfe.png|left|200px]]


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{{STRUCTURE_1yfe|  PDB=1yfe  |  SCENE=  }}  
{{STRUCTURE_1yfe|  PDB=1yfe  |  SCENE=  }}  


'''Crystal structure of apo fumarase C from Escherichia coli'''
===Crystal structure of apo fumarase C from Escherichia coli===




==Overview==
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Previous crystal structures of fumarase C from Escherichia coli have noted two occupied dicarboxylate-binding sites termed the active site and the B site. Here, the first known fumarase C structure is reported in which both sites are unoccupied by bound ligand. This so-called ;free' crystal form shows conservation of the active-site water in a similar orientation to that reported in other fumarase C crystal structures. More importantly, a shift of His129 has been observed at the B site. This new crystallographic information suggests the use of water as a permanent member of the active site and the use of an imidazole-imidazolium conversion to control access at the allosteric B site.
The line below this paragraph, {{ABSTRACT_PUBMED_16204892}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16204892}}


==About this Structure==
==About this Structure==
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[[Category: Fumarase]]
[[Category: Fumarase]]
[[Category: Kreb's cycle]]
[[Category: Kreb's cycle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:15:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:36:03 2008''

Revision as of 11:36, 29 July 2008

File:1yfe.png

Template:STRUCTURE 1yfe

Crystal structure of apo fumarase C from Escherichia coli

Template:ABSTRACT PUBMED 16204892

About this Structure

1YFE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of free fumarase C from Escherichia coli., Weaver T, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1395-401. Epub, 2005 Sep 28. PMID:16204892

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