1jxs: Difference between revisions

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[[Image:1jxs.gif|left|200px]]
{{Seed}}
[[Image:1jxs.png|left|200px]]


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{{STRUCTURE_1jxs|  PDB=1jxs  |  SCENE=  }}  
{{STRUCTURE_1jxs|  PDB=1jxs  |  SCENE=  }}  


'''Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor'''
===Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor===




==Overview==
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Interleukin enhancer binding factor (ILF) binds to the interleukin-2 (IL-2) promoter and regulates IL-2 gene expression. In this study, the 3D structure of the DNA-binding domain of ILF was determined by multidimensional NMR spectroscopy. NMR structure analysis revealed that the DNA-binding domain of ILF is a new member of the winged helix/forkhead family, and that its wing 2 contains an extra alpha-helix. This is the first study to report the presence of a C-terminal alpha-helix in place of a typical wing 2 in a member of this family. This structural difference may be responsible for the different DNA-binding specificity of ILF compared to other winged helix/forkhead proteins. Our deletion studies of the fragments of ILF also suggest that the C-terminal region plays a regulatory role in DNA binding.
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{{ABSTRACT_PUBMED_12402362}}


==About this Structure==
==About this Structure==
1JXS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXS OCA].  
1JXS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXS OCA].  


==Reference==
==Reference==
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[[Category: Dna-binding domain]]
[[Category: Dna-binding domain]]
[[Category: Winged helix]]
[[Category: Winged helix]]
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