2p8d: Difference between revisions

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[[Image:2p8d.jpg|left|200px]]
{{Seed}}
[[Image:2p8d.png|left|200px]]


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{{STRUCTURE_2p8d|  PDB=2p8d  |  SCENE=  }}  
{{STRUCTURE_2p8d|  PDB=2p8d  |  SCENE=  }}  


'''The Structure of the Dickerson Sequence with an Incorporated CeNA Residue'''
===The Structure of the Dickerson Sequence with an Incorporated CeNA Residue===




==Overview==
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Cyclohexene nucleic acids (CeNA), which are characterized by the presence of a cyclohexene moiety instead of a natural (deoxy)ribose sugar, are known to increase the thermal and enzymatic stability when incorporated in RNA oligonucleotides. As it has been demonstrated that even a single cyclohexenyl nucleoside, when incorporated in an oligonucleotide, can have a profound effect on the biological activity of the oligonucleotide, further research is warranted to study the complex of such oligonucleotides with target proteins. In order to analyse the influence of CeNA residues onto the helix conformation and hydration of natural nucleic acid structures, a cyclohexenyl-adenine building block (xAr) was incorporated into the Dickerson sequence CGCGA(xAr)TTCGCG. The crystal structure of this sequence determined to a resolution of 1.90 A. The global helix belongs to the B-type family and shows a water spine, which is partially broken up by the apolar cyclohexene residue. The cyclohexene ring adopts the (2)E-conformation allowing a better incorporation of the residue in the dodecamer sequence. The crystal packing is stabilized by cobalt hexamine residues and belongs to space group P222(1), never before reported for nucleic acids.
The line below this paragraph, {{ABSTRACT_PUBMED_18160414}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18160414 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18160414}}


==About this Structure==
==About this Structure==
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[[Category: Dna]]
[[Category: Dna]]
[[Category: Sugar modification]]
[[Category: Sugar modification]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:35:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:41:31 2008''

Revision as of 11:41, 29 July 2008

File:2p8d.png

Template:STRUCTURE 2p8d

The Structure of the Dickerson Sequence with an Incorporated CeNA Residue

Template:ABSTRACT PUBMED 18160414

About this Structure

2P8D is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Influence of the incorporation of a cyclohexenyl nucleic acid (CeNA) residue onto the sequence d(CGCGAATTCGCG)., Robeyns K, Herdewijn P, Van Meervelt L, Nucleic Acids Res. 2007 Dec 26;. PMID:18160414

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