3cid: Difference between revisions

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[[Image:3cid.jpg|left|200px]]
{{Seed}}
[[Image:3cid.png|left|200px]]


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{{STRUCTURE_3cid|  PDB=3cid  |  SCENE=  }}  
{{STRUCTURE_3cid|  PDB=3cid  |  SCENE=  }}  


'''Structure of BACE Bound to SCH726222'''
===Structure of BACE Bound to SCH726222===




==Overview==
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Guided by structure-based design, we synthesized two novel series of potent inhibitors of BACE1 and generated extensive SAR around both the prime and non-prime side binding pockets. The key feature of both series is a cyclic amine motif specifically crafted to achieve interactions with both the flap and with the S2' pocket.
The line below this paragraph, {{ABSTRACT_PUBMED_18468890}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18468890 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18468890}}


==About this Structure==
==About this Structure==
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[[Category: Bace1]]
[[Category: Bace1]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:49:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:45:26 2008''