1xfh: Difference between revisions

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[[Image:1xfh.~~gif~~|left|200px]]

[[Image:1xfh.png|left|200px]]

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~~'''~~Structure of glutamate transporter homolog from Pyrococcus horikoshii~~'''~~

===Structure of glutamate transporter homolog from Pyrococcus horikoshii===

~~==Overview==~~

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~~Glutamate transporters are integral membrane proteins that catalyse the concentrative uptake of glutamate from~~ the ~~synapse~~ to ~~intracellular spaces by harnessing pre-existing ion gradients. In~~ the ~~central nervous system glutamate transporters are essential for normal development and function, and are implicated in stroke, epilepsy and neurodegenerative diseases~~. ~~Here we present the crystal structure of a eukaryotic glutamate transporter homologue from Pyrococcus horikoshii~~. ~~The transporter is a bowl-shaped trimer with a solvent-filled extracellular basin extending halfway across the membrane bilayer. At the bottom of the basin are three independent binding sites~~, ~~each cradled by two helical hairpins, reaching from opposite sides of the membrane. We propose that transport of glutamate~~ is ~~achieved by movements of the hairpins that allow alternating access to either side of~~ the ~~membrane~~.

The line below this paragraph, {{ABSTRACT_PUBMED_15483603}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15483603 is the PubMed ID number.

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==About this Structure==

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[[Category: Yernool, D.]]

[[Category: Trimeric helical transmembrane protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3~~ 14:57:43 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:57:02 2008''

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-[[Image:1xfh.gif|left|200px]]
+{{Seed}}
+[[Image:1xfh.png|left|200px]]
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 {{STRUCTURE_1xfh|  PDB=1xfh  |  SCENE=  }}
-'''Structure of glutamate transporter homolog from Pyrococcus horikoshii'''
+===Structure of glutamate transporter homolog from Pyrococcus horikoshii===
-==Overview==
+<!--
-Glutamate transporters are integral membrane proteins that catalyse the concentrative uptake of glutamate from the synapse to intracellular spaces by harnessing pre-existing ion gradients. In the central nervous system glutamate transporters are essential for normal development and function, and are implicated in stroke, epilepsy and neurodegenerative diseases. Here we present the crystal structure of a eukaryotic glutamate transporter homologue from Pyrococcus horikoshii. The transporter is a bowl-shaped trimer with a solvent-filled extracellular basin extending halfway across the membrane bilayer. At the bottom of the basin are three independent binding sites, each cradled by two helical hairpins, reaching from opposite sides of the membrane. We propose that transport of glutamate is achieved by movements of the hairpins that allow alternating access to either side of the membrane.
+The line below this paragraph, {{ABSTRACT_PUBMED_15483603}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15483603 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15483603}}
 ==About this Structure==
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 [[Category: Yernool, D.]]
 [[Category: Trimeric helical transmembrane protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:57:43 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:57:02 2008''