1uzp: Difference between revisions

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[[Image:1uzp.gif|left|200px]]
{{Seed}}
[[Image:1uzp.png|left|200px]]


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{{STRUCTURE_1uzp|  PDB=1uzp  |  SCENE=  }}  
{{STRUCTURE_1uzp|  PDB=1uzp  |  SCENE=  }}  


'''INTEGRIN BINDING CBEGF22-TB4-CBEGF33 FRAGMENT OF HUMAN FIBRILLIN-1, SM BOUND FORM CBEGF23 DOMAIN ONLY.'''
===INTEGRIN BINDING CBEGF22-TB4-CBEGF33 FRAGMENT OF HUMAN FIBRILLIN-1, SM BOUND FORM CBEGF23 DOMAIN ONLY.===




==Overview==
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Human fibrillin-1, the major structural protein of extracellular matrix (ECM) 10-12 nm microfibrils, is dominated by 43 calcium binding epidermal growth factor-like (cbEGF) and 7 transforming growth factor beta binding protein-like (TB) domains. Crystal structures reveal the integrin binding cbEGF22-TB4-cbEGF23 fragment of human fibrillin-1 to be a Ca(2+)-rigidified tetragonal pyramid. We suggest that other cbEGF-TB pairs within the fibrillins may adopt a similar orientation to cbEGF22-TB4. In addition, we have located a flexible RGD integrin binding loop within TB4. Modeling, cell attachment and spreading assays, immunocytochemistry, and surface plasmon resonance indicate that cbEGF22 bound to TB4 is a requirement for integrin activation and provide insight into the molecular basis of the fibrillin-1 interaction with alphaVbeta3. In light of our data, we propose a novel model for the assembly of the fibrillin microfibril and a mechanism to explain its extensibility.
The line below this paragraph, {{ABSTRACT_PUBMED_15062093}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15062093 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15062093}}


==About this Structure==
==About this Structure==
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[[Category: Matrix protein]]
[[Category: Matrix protein]]
[[Category: Tb domain]]
[[Category: Tb domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:54:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:59:49 2008''

Revision as of 11:59, 29 July 2008

File:1uzp.png

Template:STRUCTURE 1uzp

INTEGRIN BINDING CBEGF22-TB4-CBEGF33 FRAGMENT OF HUMAN FIBRILLIN-1, SM BOUND FORM CBEGF23 DOMAIN ONLY.

Template:ABSTRACT PUBMED 15062093

About this Structure

1UZP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization., Lee SS, Knott V, Jovanovic J, Harlos K, Grimes JM, Choulier L, Mardon HJ, Stuart DI, Handford PA, Structure. 2004 Apr;12(4):717-29. PMID:15062093

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