1zla: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
[[Image:1zla.gif|left|200px]]
{{Seed}}
[[Image:1zla.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1zla|  PDB=1zla  |  SCENE=  }}  
{{STRUCTURE_1zla|  PDB=1zla  |  SCENE=  }}  


'''X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core'''
===X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core===




==Overview==
<!--  
Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) mediates viral genome attachment to mitotic chromosomes. We find that N-terminal LANA docks onto chromosomes by binding nucleosomes through the folded region of histones H2A-H2B. The same LANA residues were required for both H2A-H2B binding and chromosome association. Further, LANA did not bind Xenopus sperm chromatin, which is deficient in H2A-H2B; chromatin binding was rescued after assembly of nucleosomes containing H2A-H2B. We also describe the 2.9-angstrom crystal structure of a nucleosome complexed with the first 23 LANA amino acids. The LANA peptide forms a hairpin that interacts exclusively with an acidic H2A-H2B region that is implicated in the formation of higher order chromatin structure. Our findings present a paradigm for how nucleosomes may serve as binding platforms for viral and cellular proteins and reveal a previously unknown mechanism for KSHV latency.
The line below this paragraph, {{ABSTRACT_PUBMED_16469929}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16469929 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16469929}}


==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Nucleosome core particle]]
[[Category: Nucleosome core particle]]
[[Category: Protein/protein interaction]]
[[Category: Protein/protein interaction]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:45:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:07:59 2008''

Revision as of 12:08, 29 July 2008

File:1zla.png

Template:STRUCTURE 1zla

X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core

Template:ABSTRACT PUBMED 16469929

About this Structure

1ZLA is a Protein complex structure of sequences from Homo sapiens, Xenopus laevis and Other sequences. Full crystallographic information is available from OCA.

Reference

The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA., Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Joukov V, Walter JC, Luger K, Kaye KM, Science. 2006 Feb 10;311(5762):856-61. PMID:16469929

Page seeded by OCA on Tue Jul 29 15:07:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1zla&oldid=746382"