3b31: Difference between revisions

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[[Image:3b31.jpg|left|200px]]
{{Seed}}
[[Image:3b31.png|left|200px]]


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{{STRUCTURE_3b31|  PDB=3b31  |  SCENE=  }}  
{{STRUCTURE_3b31|  PDB=3b31  |  SCENE=  }}  


'''Crystal structure of domain III of the Cricket Paralysis Virus IRES RNA'''
===Crystal structure of domain III of the Cricket Paralysis Virus IRES RNA===




==Overview==
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Internal ribosome entry site (IRES) RNAs initiate protein synthesis in eukaryotic cells by a noncanonical cap-independent mechanism. IRESes are critical for many pathogenic viruses, but efforts to understand their function are complicated by the diversity of IRES sequences as well as by limited high-resolution structural information. The intergenic region (IGR) IRESes of the Dicistroviridae viruses are powerful model systems to begin to understand IRES function. Here we present the crystal structure of a Dicistroviridae IGR IRES domain that interacts with the ribosome's decoding groove. We find that this RNA domain precisely mimics the transfer RNA anticodon-messenger RNA codon interaction, and its modeled orientation on the ribosome helps explain translocation without peptide bond formation. When combined with a previous structure, this work completes the first high-resolution description of an IRES RNA and provides insight into how RNAs can manipulate complex biological machines.
The line below this paragraph, {{ABSTRACT_PUBMED_18157151}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18157151 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18157151}}


==About this Structure==
==About this Structure==
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[[Category: Trna anticodon]]
[[Category: Trna anticodon]]
[[Category: Trna mimicry]]
[[Category: Trna mimicry]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:20:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:15:57 2008''

Revision as of 12:16, 29 July 2008

File:3b31.png

Template:STRUCTURE 3b31

Crystal structure of domain III of the Cricket Paralysis Virus IRES RNA

Template:ABSTRACT PUBMED 18157151

About this Structure

3B31 is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

tRNA-mRNA mimicry drives translation initiation from a viral IRES., Costantino DA, Pfingsten JS, Rambo RP, Kieft JS, Nat Struct Mol Biol. 2008 Jan;15(1):57-64. Epub 2007 Dec 23. PMID:18157151

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