1xof: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1xof.gif|left|200px]]
{{Seed}}
[[Image:1xof.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1xof|  PDB=1xof  |  SCENE=  }}  
{{STRUCTURE_1xof|  PDB=1xof  |  SCENE=  }}  


'''Heterooligomeric Beta Beta Alpha Miniprotein'''
===Heterooligomeric Beta Beta Alpha Miniprotein===




==Overview==
<!--
The study of short, autonomously folding peptides, or "miniproteins," is important for advancing our understanding of protein stability and folding specificity. Although many examples of synthetic alpha-helical structures are known, relatively few mixed alpha/beta structures have been successfully designed. Only one mixed-secondary structure oligomer, an alpha/beta homotetramer, has been reported thus far. In this report, we use structural analysis and computational design to convert this homotetramer into the smallest known alpha/beta-heterotetramer. Computational screening of many possible sequence/structure combinations led efficiently to the design of short, 21-residue peptides that fold cooperatively and autonomously into a specific complex in solution. A 1.95 A crystal structure reveals how steric complementarity and charge patterning encode heterospecificity. The first- and second-generation heterotetrameric miniproteins described here will be useful as simple models for the analysis of protein-protein interaction specificity and as structural platforms for the further elaboration of folding and function.
The line below this paragraph, {{ABSTRACT_PUBMED_15698566}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15698566 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15698566}}


==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Heterotetramer]]
[[Category: Heterotetramer]]
[[Category: Protein design]]
[[Category: Protein design]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:17:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:20:27 2008''

Revision as of 12:20, 29 July 2008

File:1xof.png

Template:STRUCTURE 1xof

Heterooligomeric Beta Beta Alpha Miniprotein

Template:ABSTRACT PUBMED 15698566

About this Structure

Full crystallographic information is available from OCA.

Reference

Design of a heterospecific, tetrameric, 21-residue miniprotein with mixed alpha/beta structure., Ali MH, Taylor CM, Grigoryan G, Allen KN, Imperiali B, Keating AE, Structure. 2005 Feb;13(2):225-34. PMID:15698566

Page seeded by OCA on Tue Jul 29 15:20:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1xof&oldid=746806"