1w7p: Difference between revisions

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[[Image:1w7p.jpg|left|200px]]
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[[Image:1w7p.png|left|200px]]


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{{STRUCTURE_1w7p|  PDB=1w7p  |  SCENE=  }}  
{{STRUCTURE_1w7p|  PDB=1w7p  |  SCENE=  }}  


'''THE CRYSTAL STRUCTURE OF ENDOSOMAL COMPLEX ESCRT-II (VPS22/VPS25/VPS36)'''
===THE CRYSTAL STRUCTURE OF ENDOSOMAL COMPLEX ESCRT-II (VPS22/VPS25/VPS36)===




==Overview==
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ESCRT-I, -II, and -III protein complexes are sequentially recruited to endosomal membranes, where they orchestrate protein sorting and MVB biogenesis. In addition, they play a critical role in retrovirus budding. Structural understanding of ESCRT interaction networks is largely lacking. The 3.6 A structure of the yeast ESCRT-II core presented here reveals a trilobal complex containing two copies of Vps25, one copy of Vps22, and the C-terminal region of Vps36. Unexpectedly, the entire ESCRT-II core consists of eight repeats of a common building block, a "winged helix" domain. Two PPXY-motifs from Vps25 are involved in contacts with Vps22 and Vps36, and their mutation leads to ESCRT-II disruption. We show that purified ESCRT-II binds directly to the Vps20 component of ESCRT-III. Surprisingly, this binding does not require the protruding N-terminal coiled-coil of Vps22. Vps25 is the chief subunit responsible for Vps20 recruitment. This interaction dramatically increases binding of both components to lipid vesicles in vitro.
The line below this paragraph, {{ABSTRACT_PUBMED_15469844}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15469844 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15469844}}


==About this Structure==
==About this Structure==
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[[Category: Vps25]]
[[Category: Vps25]]
[[Category: Vps36]]
[[Category: Vps36]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:16:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:23:43 2008''

Revision as of 12:23, 29 July 2008

File:1w7p.png

Template:STRUCTURE 1w7p

THE CRYSTAL STRUCTURE OF ENDOSOMAL COMPLEX ESCRT-II (VPS22/VPS25/VPS36)

Template:ABSTRACT PUBMED 15469844

About this Structure

1W7P is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes., Teo H, Perisic O, Gonzalez B, Williams RL, Dev Cell. 2004 Oct;7(4):559-69. PMID:15469844

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