2xbd: Difference between revisions

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[[Image:2xbd.jpg|left|200px]]
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[[Image:2xbd.png|left|200px]]


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{{STRUCTURE_2xbd|  PDB=2xbd  |  SCENE=  }}  
{{STRUCTURE_2xbd|  PDB=2xbd  |  SCENE=  }}  


'''INTERNAL XYLAN BINDING DOMAIN FROM CELLULOMONAS FIMI XYLANASE D, NMR, MINIMIZED AVERAGE STRUCTURE'''
===INTERNAL XYLAN BINDING DOMAIN FROM CELLULOMONAS FIMI XYLANASE D, NMR, MINIMIZED AVERAGE STRUCTURE===




==Overview==
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BACKGROUND: Many enzymes that digest polysaccharides contain separate polysaccharide-binding domains. Structures have been previously determined for a number of cellulose-binding domains (CBDs) from cellulases. RESULTS: The family IIb xylan-binding domain 1 (XBD1) from Cellulomonas fimi xylanase D is shown to bind xylan but not cellulose. Its structure is similar to that of the homologous family IIa CBD from C. fimi Cex, consisting of two four-stranded beta sheets that form a twisted 'beta sandwich'. The xylan-binding site is a groove made from two tryptophan residues that stack against the faces of the sugar rings, plus several hydrogen-bonding polar residues. CONCLUSIONS: The biggest difference between the family IIa and IIb domains is that in the former the solvent-exposed tryptophan sidechains are coplanar, whereas in the latter they are perpendicular, forming a twisted binding site. The binding sites are therefore complementary to the secondary structures of the ligands cellulose and xylan. XBD1 and CexCBD represent a striking example of two proteins that have high sequence similarity but a different function.
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{{ABSTRACT_PUBMED_10425686}}


==About this Structure==
==About this Structure==
2XBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cellulomonas_fimi Cellulomonas fimi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XBD OCA].  
2XBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cellulomonas_fimi Cellulomonas fimi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XBD OCA].  


==Reference==
==Reference==
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[[Category: Xylan binding domain]]
[[Category: Xylan binding domain]]
[[Category: Xylanase]]
[[Category: Xylanase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 19:10:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:25:38 2008''

Revision as of 12:25, 29 July 2008

File:2xbd.png

Template:STRUCTURE 2xbd

INTERNAL XYLAN BINDING DOMAIN FROM CELLULOMONAS FIMI XYLANASE D, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 10425686

About this Structure

2XBD is a Single protein structure of sequence from Cellulomonas fimi. Full experimental information is available from OCA.

Reference

A family IIb xylan-binding domain has a similar secondary structure to a homologous family IIa cellulose-binding domain but different ligand specificity., Simpson PJ, Bolam DN, Cooper A, Ciruela A, Hazlewood GP, Gilbert HJ, Williamson MP, Structure. 1999 Jul 15;7(7):853-64. PMID:10425686

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