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| [[Image:1od5.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1od5| PDB=1od5 | SCENE= }} | | {{STRUCTURE_1od5| PDB=1od5 | SCENE= }} |
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| '''CRYSTAL STRUCTURE OF GLYCININ A3B4 SUBUNIT HOMOHEXAMER'''
| | ===CRYSTAL STRUCTURE OF GLYCININ A3B4 SUBUNIT HOMOHEXAMER=== |
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| ==Overview==
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| Most plant seeds contain 11S globulins as major storage proteins for their nutrition. Soybean glycinin belongs to the 11S globulin family and consists of five kinds of subunits. We determined the crystal structure of a homohexamer of the glycinin A3B4 subunit at 2.1-A resolution. The crystal structure shows that the hexamer has 32-point group symmetry formed by face-to-face stacking of two trimers. The interface buries the highly conserved interchain disulfide. Based on the structure, we propose that an ingenious face-to-face mechanism controls the hexamer formation of the 11S globulin by movement of a mobile disordered region to the side of the trimer after posttranslational processing. Electrostatic analysis of the faces suggests that the interchain disulfide-containing face has high positive potential at acidic pH, which induces dissociation of the hexamer into trimers that may be susceptible to proteinases after seed imbibition. This dissociation might result in the degradation and mobilization of 11S globulins as storage proteins in embryos during germination and seedling growth.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12771376}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12771376 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12771376}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Glycinin]] | | [[Category: Glycinin]] |
| [[Category: Soybean]] | | [[Category: Soybean]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:41:35 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:40:01 2008'' |
