1syv: Difference between revisions

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[[Image:1syv.gif|left|200px]]
{{Seed}}
[[Image:1syv.png|left|200px]]


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{{STRUCTURE_1syv|  PDB=1syv  |  SCENE=  }}  
{{STRUCTURE_1syv|  PDB=1syv  |  SCENE=  }}  


'''HLA-B*4405 complexed to the dominant self ligand EEFGRAYGF'''
===HLA-B*4405 complexed to the dominant self ligand EEFGRAYGF===




==Overview==
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HLA class I polymorphism creates diversity in epitope specificity and T cell repertoire. We show that HLA polymorphism also controls the choice of Ag presentation pathway. A single amino acid polymorphism that distinguishes HLA-B*4402 (Asp116) from B*4405 (Tyr116) permits B*4405 to constitutively acquire peptides without any detectable incorporation into the transporter associated with Ag presentation (TAP)-associated peptide loading complex even under conditions of extreme peptide starvation. This mode of peptide capture is less susceptible to viral interference than the conventional loading pathway used by HLA-B*4402 that involves assembly of class I molecules within the peptide loading complex. Thus, B*4402 and B*4405 are at opposite extremes of a natural spectrum in HLA class I dependence on the PLC for Ag presentation. These findings unveil a new layer of MHC polymorphism that affects the generic pathway of Ag loading, revealing an unsuspected evolutionary trade-off in selection for optimal HLA class I loading versus effective pathogen evasion.
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{{ABSTRACT_PUBMED_15226359}}


==Disease==
==Disease==
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[[Category: Hla]]
[[Category: Hla]]
[[Category: Mhc]]
[[Category: Mhc]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:17:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:47:59 2008''

Revision as of 12:48, 29 July 2008

File:1syv.png

Template:STRUCTURE 1syv

HLA-B*4405 complexed to the dominant self ligand EEFGRAYGF

Template:ABSTRACT PUBMED 15226359

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1SYV is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion., Zernich D, Purcell AW, Macdonald WA, Kjer-Nielsen L, Ely LK, Laham N, Crockford T, Mifsud NA, Bharadwaj M, Chang L, Tait BD, Holdsworth R, Brooks AG, Bottomley SP, Beddoe T, Peh CA, Rossjohn J, McCluskey J, J Exp Med. 2004 Jul 5;200(1):13-24. Epub 2004 Jun 28. PMID:15226359

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