2gwl: Difference between revisions

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[[Image:2gwl.gif|left|200px]]
{{Seed}}
[[Image:2gwl.png|left|200px]]


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{{STRUCTURE_2gwl|  PDB=2gwl  |  SCENE=  }}  
{{STRUCTURE_2gwl|  PDB=2gwl  |  SCENE=  }}  


'''Crystal structure of the Salmonella SpvB ATR Domain in complex with NADH'''
===Crystal structure of the Salmonella SpvB ATR Domain in complex with NADH===




==Overview==
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Salmonella spp. require the ADP-ribosyltransferase activity of the SpvB protein for intracellular growth and systemic virulence. SpvB covalently modifies actin, causing cytoskeletal disruption and apoptosis. We report here the crystal structure of the catalytic domain of SpvB, and we show by mass spectrometric analysis that SpvB modifies actin at Arg177, inhibiting its ATPase activity. We also describe two crystal structures of SpvB-modified, polymerization-deficient actin. These structures reveal that ADP-ribosylation does not lead to dramatic conformational changes in actin, suggesting a model in which this large family of toxins inhibits actin polymerization primarily through steric disruption of intrafilament contacts.
The line below this paragraph, {{ABSTRACT_PUBMED_16905096}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16905096 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16905096}}


==About this Structure==
==About this Structure==
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[[Category: Salmonella]]
[[Category: Salmonella]]
[[Category: Spvb]]
[[Category: Spvb]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:37:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:05:25 2008''
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