1qgp: Difference between revisions

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[[Image:1qgp.~~jpg~~|left|200px]]

[[Image:1qgp.png|left|200px]]

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~~'''~~NMR STRUCTURE OF THE Z-ALPHA DOMAIN OF ADAR1, 15 STRUCTURES~~'''~~

===NMR STRUCTURE OF THE Z-ALPHA DOMAIN OF ADAR1, 15 STRUCTURES===

~~==Overview==~~

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~~Double~~-~~stranded RNA deaminase I (ADAR1) contains the Z~~-~~DNA binding domain Zalpha. Here we report~~ the ~~solution structure of free Zalpha and map the interaction surface with Z-DNA, confirming roles previously assigned~~ to ~~residues by mutagenesis. Comparison with the crystal structure of~~ the (~~Zalpha)(2)~~/~~Z-DNA complex shows that most Z-DNA contacting residues in free Zalpha are prepositioned to bind Z-DNA, thus minimizing the entropic cost of binding~~. ~~Comparison with homologous (alpha+beta~~)~~helix-turn-helix/B-DNA complexes suggests that binding of Zalpha to B-DNA~~ is ~~disfavored by steric hindrance, but does not eliminate~~ the ~~possibility that related domains may bind to both B~~- ~~and Z~~-~~DNA.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10535945}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10535945 is the PubMed ID number.

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==About this Structure==

1QGP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGP OCA].

1QGP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGP OCA].

==Reference==

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[[Category: Z-alpha-z-dna binding domain]]

[[Category: Z-dna recognition]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06~~:14:57 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:12:22 2008''

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-[[Image:1qgp.jpg|left|200px]]
+{{Seed}}
+[[Image:1qgp.png|left|200px]]
 <!--
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 {{STRUCTURE_1qgp|  PDB=1qgp  |  SCENE=  }}
-'''NMR STRUCTURE OF THE Z-ALPHA DOMAIN OF ADAR1, 15 STRUCTURES'''
+===NMR STRUCTURE OF THE Z-ALPHA DOMAIN OF ADAR1, 15 STRUCTURES===
-==Overview==
+<!--
-Double-stranded RNA deaminase I (ADAR1) contains the Z-DNA binding domain Zalpha. Here we report the solution structure of free Zalpha and map the interaction surface with Z-DNA, confirming roles previously assigned to residues by mutagenesis. Comparison with the crystal structure of the (Zalpha)(2)/Z-DNA complex shows that most Z-DNA contacting residues in free Zalpha are prepositioned to bind Z-DNA, thus minimizing the entropic cost of binding. Comparison with homologous (alpha+beta)helix-turn-helix/B-DNA complexes suggests that binding of Zalpha to B-DNA is disfavored by steric hindrance, but does not eliminate the possibility that related domains may bind to both B- and Z-DNA.
+The line below this paragraph, {{ABSTRACT_PUBMED_10535945}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10535945 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10535945}}
 ==About this Structure==
-QGP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGP OCA].
+QGP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGP OCA].
 ==Reference==
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 [[Category: Z-alpha-z-dna binding domain]]
 [[Category: Z-dna recognition]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:14:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:12:22 2008''