2czu: Difference between revisions

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[[Image:2czu.gif|left|200px]]
{{Seed}}
[[Image:2czu.png|left|200px]]


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{{STRUCTURE_2czu|  PDB=2czu  |  SCENE=  }}  
{{STRUCTURE_2czu|  PDB=2czu  |  SCENE=  }}  


'''lipocalin-type prostaglandin D synthase'''
===lipocalin-type prostaglandin D synthase===




==Overview==
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Lipocalin-type prostaglandin D synthase is the key enzyme for the production of prostaglandin D(2), a potent endogenous somnogen, in the brain. We cloned, produced, and crystallized the native enzyme and selenomethionyl Cys(65)Ala mutants of the recombinant mouse protein by the hanging drop vapor-diffusion method with both malonate and citrate as precipitants. The native crystals obtained with malonate belong to orthorhombic space group P2(1)2(1)2(1) with lattice constants a = 46.2, b = 66.8, and c = 105.3 A. The selenomethionyl crystals obtained with citrate belong to orthorhombic space group C222(1) with lattice constants a = 45.5, b = 66.8, and c = 104.5 A. The native crystals diffracted beyond 2.1 A resolution.
The line below this paragraph, {{ABSTRACT_PUBMED_12761195}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12761195 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12761195}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme., Irikura D, Kumasaka T, Yamamoto M, Ago H, Miyano M, Kubata KB, Sakai H, Hayaishi O, Urade Y, J Biochem. 2003 Jan;133(1):29-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12761195 12761195]
Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme., Irikura D, Kumasaka T, Yamamoto M, Ago H, Miyano M, Kubata KB, Sakai H, Hayaishi O, Urade Y, J Biochem. 2003 Jan;133(1):29-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12761195 12761195]
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice., Eguchi N, Minami T, Shirafuji N, Kanaoka Y, Tanaka T, Nagata A, Yoshida N, Urade Y, Ito S, Hayaishi O, Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):726-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9892701 9892701]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Prostaglandin-D synthase]]
[[Category: Prostaglandin-D synthase]]
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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