Sandbox 46: Difference between revisions
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{{STRUCTURE_1w68 | PDB=1w68 | SCENE= }} | |||
{{STRUCTURE_1w69 | PDB=1w69 | SCENE= }} | |||
==Mouse Ribonucleotide Reductase == | |||
Protein ID: | |||
1w68 (under oxidizing conditions) | |||
1w69 (under reducing conditions) | |||
==Introduction== | |||
==Structual Properties== | |||
While both forms of this enzyme both interact with iron, there are some structural differences due to the different conditions. | |||
1w68: | |||
16 α-helices | |||
8 β-turns | |||
1w69: | |||
15 α-helices | |||
10 β-turns | |||
==Protein Sequence== | |||
For the enzyme under oxidizing conditions (1w68): | |||
VEDEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFA | |||
ASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREYLFNAIETMPCVK | |||
KKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFA | |||
CLMFKHLVHKPAEQRVREIITNAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFR | |||
VENPF | |||
For the enzyme under reducing conditions(1w69): | |||
VEDEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFA | |||
ASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREYLFNAIETMPCVK | |||
KKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFA | |||
CLMFKHLVHKPAEQRVREIITNAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFR | |||
VENPF | |||
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