User:Wayne Decatur/Sandbox: Difference between revisions
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{{STRUCTURE_1r9f | PDB= 1r9f | SCENE= }} | {{STRUCTURE_1r9f | PDB= 1r9f | SCENE= }} | ||
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{{STRUCTURE_1eve | PDB= 1eve | SCENE=Main_Page/E2020_in_ache_spinning/1 }} | |||
The collaborative, 3D encyclopedia of proteins and other molecules. | |||
===<span style="color:green">Green</span> links change the 3D image!=== | |||
<big>''Here's an excerpt from one of our pages ([[1eve]]):''</big> | |||
The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/12'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/6'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/4'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/7'>indirectly via solvent molecules</scene>'''. | |||
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