2oar: Difference between revisions

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===Mechanosensitive Channel of Large Conductance (MscL)===

==Model of Channel Opening==

Models the <scene name='Goodsell_Sandbox/1kyk/1'>closed, </scene><scene name='Goodsell_Sandbox/1kyl/1'>intermediate,</scene> and <scene name='Goodsell_Sandbox/1kym/1'>open</scene> forms of the channel have been generated based on data from electron paramagnetic resonance spectroscopy, using mutant forms of the protein with spin labels attached to engineered cysteine amino acids in the transmembrane segments<ref>Open channel structure of MscL and the gating mechanism of mechanosensitive channels. Perozo, E, Cortes DM, Sompornpisut, P, Kloda, A, Martinac, B. Nature 2002, 418, 942-948. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12198539 12198539]</ref>.

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2OAR <ref>Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel., Chang G, Spencer RH, Lee AT, Barclay MT, Rees DC, Science. 1998 Dec 18;282(5397):2220-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9856938 9856938]</ref> is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1msl 1msl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAR OCA].

~~==Model of Channel Opening==~~

Models the <scene name='Goodsell_Sandbox/1kyk/1'>closed, </scene><scene name='Goodsell_Sandbox/1kyl/1'>intermediate,</scene> and <scene name='Goodsell_Sandbox/1kym/1'>open</scene> forms of the channel have been generated based on data from electron paramagnetic resonance spectroscopy, using mutant forms of the protein with spin labels attached to engineered cysteine amino acids in the transmembrane segments<ref>Open channel structure of MscL and the gating mechanism of mechanosensitive channels. Perozo, E, Cortes DM, Sompornpisut, P, Kloda, A, Martinac, B. Nature 2002, 418, 942-948. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12198539 12198539]</ref>.

==Reference==

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@@ Line 12: / Line 12: @@
 ===Mechanosensitive Channel of Large Conductance (MscL)===
+==Model of Channel Opening==
+Models the <scene name='Goodsell_Sandbox/1kyk/1'>closed, </scene><scene name='Goodsell_Sandbox/1kyl/1'>intermediate,</scene> and <scene name='Goodsell_Sandbox/1kym/1'>open</scene> forms of the channel have been generated based on data from electron paramagnetic resonance spectroscopy, using mutant forms of the protein with spin labels attached to engineered cysteine amino acids in the transmembrane segments<ref>Open channel structure of MscL and the gating mechanism of mechanosensitive channels. Perozo, E, Cortes DM, Sompornpisut, P, Kloda, A, Martinac, B. Nature 2002, 418, 942-948. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12198539 12198539]</ref>.
 <!--
@@ Line 22: / Line 24: @@
 OAR <ref>Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel., Chang G, Spencer RH, Lee AT, Barclay MT, Rees DC, Science. 1998 Dec 18;282(5397):2220-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9856938 9856938]</ref> is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1msl 1msl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAR OCA].
-==Model of Channel Opening==
-Models the <scene name='Goodsell_Sandbox/1kyk/1'>closed, </scene><scene name='Goodsell_Sandbox/1kyl/1'>intermediate,</scene> and <scene name='Goodsell_Sandbox/1kym/1'>open</scene> forms of the channel have been generated based on data from electron paramagnetic resonance spectroscopy, using mutant forms of the protein with spin labels attached to engineered cysteine amino acids in the transmembrane segments<ref>Open channel structure of MscL and the gating mechanism of mechanosensitive channels. Perozo, E, Cortes DM, Sompornpisut, P, Kloda, A, Martinac, B. Nature 2002, 418, 942-948. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12198539 12198539]</ref>.
 ==Reference==