Proteopedia:Main page develop: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Eran Hodis (talk | contribs) No edit summary |
Eran Hodis (talk | contribs) No edit summary |
||
| Line 24: | Line 24: | ||
</td> | </td> | ||
<td> | <td> | ||
<div style="font-size: | <div style="font-size:200%; line-height:2.0em">[[1eve]]</div> | ||
The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/12'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/6'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/4'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/7'>indirectly via solvent molecules</scene>'''. [[1eve|Read more at 1eve...]] | The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/12'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/6'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/4'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/7'>indirectly via solvent molecules</scene>'''. [[1eve|Read more at 1eve...]] | ||
</td> | </td> | ||
| Line 40: | Line 40: | ||
<tr> | <tr> | ||
<td> | <td> | ||
<div style="font-size: | <div style="font-size:120%; line-height:2.0em">Favorites</div> | ||
* [[Hemoglobin]] - a page about | * [[Hemoglobin]] - a page about | ||
* [[HIV-1 protease]] - a page about | * [[HIV-1 protease]] - a page about | ||
