Proteopedia:Main page develop: Difference between revisions

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<div style="font-size:200%; line-height:2.0em"><span style="color:green" align="center">Green</span> links change the 3D image!</div>
<div style="font-size:130%; line-height:2.0em"><span style="color:green" align="center">Green</span> links change the 3D image!</div>
<div style="font-size:200%; line-height:2.0em">[[1eve]]</div>
<div style="font-size:200%; line-height:2.0em">[[1eve]]</div>
The anti-Alzheimer's drug E2020 (marketed as Aricept&reg;) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity.  The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/12'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/6'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/4'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/7'>indirectly via solvent molecules</scene>'''. [[1eve|Read more at 1eve...]]
The anti-Alzheimer's drug E2020 (marketed as Aricept&reg;) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity.  The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/12'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/6'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/4'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/7'>indirectly via solvent molecules</scene>'''. [[1eve|Read more at 1eve...]]
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===<span style="color:green" align="center">Green</span> links change the 3D image!===


<table style="background: #D1FFE7; border:1px solid #94FFC8" cellspacing="5px" cellpadding="10px" width="100%">  
<table style="background: #D1FFE7; border:1px solid #94FFC8" cellspacing="5px" cellpadding="10px" width="100%">  
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You may protect such pages from unwanted editing by others -- see [[Help:Protected Pages]].
You may protect such pages from unwanted editing by others -- see [[Help:Protected Pages]].


===Proteopedia Mission Statement===
To collect, organize and disseminate structural and functional knowledge about protein, RNA, DNA, and other macromolecules, and their assemblies and interactions with small molecules, in a manner that is relevant and broadly accessible to students and scientists.


===Goals for Proteopedia===
* To serve as a forum for the scientific community to share, retrieve and discuss information related to proteins, macromolecules, and small molecules and chemicals of interest.
* To continue to develop the concept of tying text to three-dimensional, interactive images.
* To maintain low barriers for contribution.
* To foster collaborations between students and experts, signed with their real names.


===About Proteopedia: How to Cite Proteopedia (''Genome Biology'' Publication) / News / Contact ===
===About Proteopedia: How to Cite Proteopedia (''Genome Biology'' Publication) / News / Contact ===
Retrieved from "https://proteopedia.org/Proteopedia:Main_page_develop"