User:Michael Lartey/Sandbox: Difference between revisions
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Humans have two cytosolic kinases (thymidine kinase 1 and deoxycytidine kinase) and two mitochondrial kinases (thymidine kinase 2 and deoxyguanosine kinase). These enzymes have different substrate specificities. Human TK1 differs from the others. Human TK1 phosphorylates has a very narrow specificity; it catalyzes the phosphorylation of only deoxythymidine (dT) and deoxyuridine. It is strictly cell-regulated and has negligible activity in resting cells. Its activity begins in late G1 cells, increases in S-phase and disappear during mitosis. | Humans have two cytosolic kinases (thymidine kinase 1 and deoxycytidine kinase) and two mitochondrial kinases (thymidine kinase 2 and deoxyguanosine kinase). These enzymes have different substrate specificities. Human TK1 differs from the others. Human TK1 phosphorylates has a very narrow specificity; it catalyzes the phosphorylation of only deoxythymidine (dT) and deoxyuridine. It is strictly cell-regulated and has negligible activity in resting cells. Its activity begins in late G1 cells, increases in S-phase and disappear during mitosis. | ||
[[Image:DT phosphorylation.png]] | [[Image:DT phosphorylation.png|center]] | ||
'''Structure and uses''' | '''Structure and uses''' | ||
