Prion protein: Difference between revisions
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There are a number of technical obstacles in determining the molecular structure of PrP(sup)Sc</sup> | There are a number of technical obstacles in determining the molecular structure of PrP(sup)Sc</sup> | ||
<ref>10</ref> | |||
=Genetic prion diseases= | =Genetic prion diseases= | ||
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All structures determined by NMR unless otherwise specified | All structures determined by NMR unless otherwise specified | ||
==Human PrP== | ==Human PrP== | ||
* [[ | * [[1qlx]] HuPrP residues 23-230 | ||
* [[ | * [[1qm0]] HuPrP residues 90-230 | ||
* [[ | * [[1qm2]] HuPrP residues 121-230 | ||
* [[ | * [[1i4m]] HuPrP residues 119-226 (determined by X-ray crystallography) | ||
* [[ | * [[1fkc]] HuPrP,E200K residues 90-231 (genetic prion disease) | ||
* [[ | * [[1h0l]] HuPrP residues 121-230, with an additional disulphide bond analogous to the homolog [[Doppel]] | ||
==Other species PrPs== | ==Other species PrPs== | ||
* | * [[1xyx]] Mouse PrP residues | ||
* [[ | * [[1b10]] Syrian hamster PrP residues 90-231 | ||
* [[ | * [[1dwy]] Cow PrP residues 121-230 | ||
* [[ | * [[1uw3]] Sheep PrP (determined by X-ray crystallography) | ||
* | * [[1xu0]] Frog PrP residues 98-226 | ||
* | * [[1u3m]] Chicken PrP | ||
* | * [[1u5l]] Turtle PrP residues 121-226 | ||
=References= | =References= | ||
{{Reflist}} <references/> | {{Reflist}} | ||
Zahn, R. ''et al.'' (2000) NMR solution structure of the human prion protein ''Proc. Natl. Acad. Sci. USA'' '''97''', 145-150 | |||
Zahn R. et al. (2003) NMR structure of a variant human prion protein with two disulfide bridges'' J. Mol. Biol.'' '''326''', 225-34. | |||
<references/> | |||
