1sa4: Difference between revisions

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==About this Structure==
==About this Structure==
1SA4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SA4 OCA].  
1SA4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SA4 OCA].  


==Reference==
==Reference==
Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity., Reid TS, Beese LS, Biochemistry. 2004 Jun 8;43(22):6877-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15170324 15170324]
<ref group="xtra">PMID:15170324</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein farnesyltransferase]]
[[Category: Protein farnesyltransferase]]
[[Category: Beese, L S.]]
[[Category: Beese, L S.]]
Line 45: Line 44:
[[Category: Zarnestra]]
[[Category: Zarnestra]]


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Revision as of 07:54, 16 February 2009

File:1sa4.png

Template:STRUCTURE 1sa4

human protein farnesyltransferase complexed with FPP and R115777

Template:ABSTRACT PUBMED 15170324

About this Structure

1SA4 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Reid TS, Beese LS. Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity. Biochemistry. 2004 Jun 8;43(22):6877-84. PMID:15170324 doi:10.1021/bi049723b

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