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==About this Structure==
==About this Structure==
3DOX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_hxb2_group_m_subtype_b) Human immunodeficiency virus type 1 (isolate hxb2 group m subtype b)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DOX OCA].  
3DOX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_hxb2_group_m_subtype_b) Human immunodeficiency virus type 1 (isolate hxb2 group m subtype b)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DOX OCA].  


==Reference==
==Reference==
X-ray structure of HIV-1 protease in situ product complex., Bihani S, Das A, Prashar V, Ferrer JL, Hosur MV, Proteins. 2008 Aug 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18704947 18704947]
<ref group="xtra">PMID:18704947</ref><ref group="xtra">PMID:11170214</ref><ref group="xtra">PMID:15794743</ref><ref group="xtra">PMID:14993705</ref><ref group="xtra">PMID:17116869</ref><references group="xtra"/>
 
1.9 A x-ray study shows closed flap conformation in crystals of tethered HIV-1 PR., Pillai B, Kannan KK, Hosur MV, Proteins. 2001 Apr 1;43(1):57-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11170214 11170214]
 
Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex., Kumar M, Prashar V, Mahale S, Hosur MV, Biochem J. 2005 Jul 15;389(Pt 2):365-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15794743 15794743]
 
Rapid screening for HIV-1 protease inhibitor leads through X-ray diffraction., Pillai B, Kannan KK, Bhat SV, Hosur MV, Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):594-6. Epub 2004, Feb 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14993705 14993705]
 
Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates., Das A, Prashar V, Mahale S, Serre L, Ferrer JL, Hosur MV, Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18464-9. Epub 2006 Nov 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17116869 17116869]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Protein complex]]
[[Category: Bihani, S.]]
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
[[Category: Das, A.]]
[[Category: Ferrer, J L.]]
[[Category: Hosur, M V.]]
[[Category: Prashar, V.]]
[[Category: Aid]]
[[Category: Aid]]
[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
Line 71: Line 66:
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 4 20:12:25 2009''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:31:51 2009''

Revision as of 15:31, 16 February 2009

File:3dox.png

Template:STRUCTURE 3dox

X-ray structure of HIV-1 protease in situ product complex

Template:ABSTRACT PUBMED 18704947

About this Structure

3DOX is a 3 chains structure of sequences from Human immunodeficiency virus type 1 (isolate hxb2 group m subtype b). Full crystallographic information is available from OCA.

Reference

  1. Bihani S, Das A, Prashar V, Ferrer JL, Hosur MV. X-ray structure of HIV-1 protease in situ product complex. Proteins. 2008 Aug 14. PMID:18704947 doi:10.1002/prot.22174
  2. Pillai B, Kannan KK, Hosur MV. 1.9 A x-ray study shows closed flap conformation in crystals of tethered HIV-1 PR. Proteins. 2001 Apr 1;43(1):57-64. PMID:11170214
  3. Kumar M, Prashar V, Mahale S, Hosur MV. Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex. Biochem J. 2005 Jul 15;389(Pt 2):365-71. PMID:15794743 doi:10.1042/BJ20041804
  4. Pillai B, Kannan KK, Bhat SV, Hosur MV. Rapid screening for HIV-1 protease inhibitor leads through X-ray diffraction. Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):594-6. Epub 2004, Feb 25. PMID:14993705 doi:10.1107/S0907444903029676
  5. Das A, Prashar V, Mahale S, Serre L, Ferrer JL, Hosur MV. Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18464-9. Epub 2006 Nov 20. PMID:17116869

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