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[[Image:2dqs.jpg|left|200px]]
{{Seed}}
[[Image:2dqs.png|left|200px]]


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{{STRUCTURE_2dqs|  PDB=2dqs  |  SCENE=  }}  
{{STRUCTURE_2dqs|  PDB=2dqs  |  SCENE=  }}  


'''Crystal structure of the calcium pump with amppcp in the absence of calcium'''
===Crystal structure of the calcium pump with amppcp in the absence of calcium===


==Overview==
Calcium ATPase is a member of the P-type ATPases that transport ions across the membrane against a concentration gradient. Here we have solved the crystal structure of the calcium ATPase of skeletal muscle sarcoplasmic reticulum (SERCA1a) at 2.6 A resolution with two calcium ions bound in the transmembrane domain, which comprises ten alpha-helices. The two calcium ions are located side by side and are surrounded by four transmembrane helices, two of which are unwound for efficient coordination geometry. The cytoplasmic region consists of three well separated domains, with the phosphorylation site in the central catalytic domain and the adenosine-binding site on another domain. The phosphorylation domain has the same fold as haloacid dehalogenase. Comparison with a low-resolution electron density map of the enzyme in the absence of calcium and with biochemical data suggests that large domain movements take place during active transport.


==About this Structure==
==About this Structure==
2DQS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DQS OCA].  
2DQS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DQS OCA].  


==Reference==
==Reference==
Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution., Toyoshima C, Nakasako M, Nomura H, Ogawa H, Nature. 2000 Jun 8;405(6787):647-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10864315 10864315]
<ref group="xtra">PMID:10864315</ref><ref group="xtra">PMID:12167852</ref><ref group="xtra">PMID:15229613</ref><ref group="xtra">PMID:15448704</ref><ref group="xtra">PMID:16150713</ref><references group="xtra"/>
[[Category: Calcium-transporting ATPase]]
[[Category: Calcium-transporting ATPase]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Single protein]]
[[Category: Norimatsu, Y.]]
[[Category: Norimatsu, Y.]]
[[Category: Toyoshima, C.]]
[[Category: Toyoshima, C.]]
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: P-type atpase]]
[[Category: P-type atpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:17:49 2009''

Revision as of 08:17, 17 February 2009

File:2dqs.png

Template:STRUCTURE 2dqs

Crystal structure of the calcium pump with amppcp in the absence of calcium

About this Structure

2DQS is a 1 chain structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

  1. Toyoshima C, Nakasako M, Nomura H, Ogawa H. Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution. Nature. 2000 Jun 8;405(6787):647-55. PMID:10864315 doi:https://dx.doi.org/10.1038/35015017
  2. Toyoshima C, Nomura H. Structural changes in the calcium pump accompanying the dissociation of calcium. Nature. 2002 Aug 8;418(6898):605-11. PMID:12167852 doi:https://dx.doi.org/10.1038/nature00944
  3. Toyoshima C, Mizutani T. Crystal structure of the calcium pump with a bound ATP analogue. Nature. 2004 Jul 29;430(6999):529-35. Epub 2004 Jun 30. PMID:15229613 doi:https://dx.doi.org/10.1038/nature02680
  4. Toyoshima C, Nomura H, Tsuda T. Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues. Nature. 2004 Nov 18;432(7015):361-8. Epub 2004 Sep 26. PMID:15448704 doi:https://dx.doi.org/10.1038/nature02981
  5. Obara K, Miyashita N, Xu C, Toyoshima I, Sugita Y, Inesi G, Toyoshima C. Structural role of countertransport revealed in Ca(2+) pump crystal structure in the absence of Ca(2+). Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14489-96. Epub 2005 Sep 6. PMID:16150713

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