1r0p: Difference between revisions

Revision as of 10:33, 17 February 2009

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1r0p.png

1r0p, resolution 1.80Å (default scene)

Ligands:

KSA

Gene:

MET (Homo sapiens)

Activity:

Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2

Structural annotation:
Resources:	CATH : 1R0Pa01, 1R0Pa02 InterPro : Ipr001245, Ipr002165, Ipr001627, Ipr000719, Ipr014756, Ipr008266, Ipr011009, Ipr002909, Ipr003659 Pfam : PF07714 SCOP : d1r0pa_ UniProt : P08581

Functional annotation:
Cellular component:	membrane fraction integral to plasma membrane membrane integral to membrane basal plasma membrane
Biological process:	myoblast proliferation muscle development hepatocyte growth factor receptor signaling pathway cell proliferation protein amino acid phosphorylation signal transduction activation of MAPK activity adult behavior brain development multicellular organismal development protein amino acid autophosphorylation cell surface receptor linked signal transduction
Molecular function:	hepatocyte growth factor receptor activity receptor activity nucleotide binding protein-tyrosine kinase activity kinase activity protein kinase activity protein binding transferase activity ATP binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a

Template:ABSTRACT PUBMED 14559966

Disease

Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]

About this Structure

1R0P is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12654-9. Epub 2003 Oct 14. PMID:14559966 doi:10.1073/pnas.1734128100

Page seeded by OCA on Tue Feb 17 12:33:29 2009

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12654-9. Epub 2003 Oct 14. PMID:14559966 doi:10.1073/pnas.1734128100

@@ Line 23: / Line 23: @@
 ==About this Structure==
-R0P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0P OCA].
+R0P is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0P OCA].
 ==Reference==
-Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a., Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C, Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12654-9. Epub 2003 Oct 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14559966 14559966]
+<ref group="xtra">PMID:14559966</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
 [[Category: Transferase]]
 [[Category: Cristiani, C.]]
@@ Line 43: / Line 42: @@
 [[Category: Signal transduction]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:54:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:33:29 2009''

1r0p: Difference between revisions

Revision as of 10:33, 17 February 2009

Contents

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a

Disease

About this Structure

Reference

Proteopedia Page Contributors and Editors (what is this?)

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