Template:SGC BRD3: Difference between revisions
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Eran Hodis (talk | contribs) |
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The interface between both BRD3 BD1 monomers covers a large mainly hydrophobic surface area suggesting that this domain might be dimeric in solution. Dimerization of bromo domains has also been suggested for the closely related protein BRD2. However, the interface which is formed in BRD2 by the two C-terminal helices is not conserved in BRD3. As expected from their high degrees of sequence conservation (78% identity) the overall fold of BRD3 is closely related to the bromo domain of BRD2 (r.m.s.d 0.7 Å between chain B BRD3 and chain A BRD2; pdb-code: [[1x0j]]). | The interface between both BRD3 BD1 monomers covers a large mainly hydrophobic surface area suggesting that this domain might be dimeric in solution. Dimerization of bromo domains has also been suggested for the closely related protein BRD2. However, the interface which is formed in BRD2 by the two C-terminal helices is not conserved in BRD3. As expected from their high degrees of sequence conservation (78% identity) the overall fold of BRD3 is closely related to the bromo domain of BRD2 (r.m.s.d 0.7 Å between chain B BRD3 and chain A BRD2; pdb-code: [[1x0j]]). | ||
