Sandbox10

This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! Brendan Jones

Myosin 2 Motor Domain

Myosin is a protein known largely for it's involvement in the contraction of the body's muscles. However, this protein can also be found in the ears and eyes, blood platelets, and it has functions in cytokinesis.

Myosin II is found in the myofibers of skeletal, smooth, and cardiac muscle tissue where the protein forms the thick filaments. The myosin of the thick filaments has the ability to bind the thin filaments, composed of actin. The myosin head then rotates and pulls the two filaments past one another providing the basis for muscle contraction.

This view shows the active sites of the protein.

alpha-helix

Thanks to Fedorov, R., Boehl, M., Tsiavaliaris, G., Hartmann, F.K., Baruch, P., Brenner, B., Martin, R., Knoelker, H.J., Gutzeit, H.O., Manstein, D.J. for their work in resolving the structure of this protein.

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='2jhr' size='350' frame='false' scene=
2jhr, resolution 2.80Å (default scene)
Ligands:	AD9, MG, PBQ
Related:	1mne, 1d1c, 1jx2, 1q5g, 1w9l, 1vom, 1d0y, 1mmn, 2aka, 1lvk, 1w9j, 1jwy, 1yv3, 1fmv, 1fmw, 1d0x, 1d1b, 1g8x, 1mma, 1d1a, 1mmg, 1w9i, 1d0z, 1mnd, 1w9k, 1mmd, 2jj9
Structural annotation: Resources: InterPro : Ipr001609, Ipr002928, Ipr000048, Ipr008989, Ipr004009 Pfam : PF00063, PF02736
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml