Sandbox16: Difference between revisions
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==Protein== | |||
A small molecule nonpeptide inhibitor of beta-secretase has been developed, and its binding has been defined through crystallographic determination of the enzyme-inhibitor complex. The molecule is shown to bind to the catalytic aspartate residues in an unprecedented manner in the field of aspartyl protease inhibition. Additionally, the complex reveals a heretofore unknown S(3) subpocket that is created by the inhibitor. This structure has served an important role in the design of newer beta-secretase inhibitors. (http://www.proteopedia.org/wiki/index.php/1tqf) | A small molecule nonpeptide inhibitor of beta-secretase has been developed, and its binding has been defined through crystallographic determination of the enzyme-inhibitor complex. The molecule is shown to bind to the catalytic aspartate residues in an unprecedented manner in the field of aspartyl protease inhibition. Additionally, the complex reveals a heretofore unknown S(3) subpocket that is created by the inhibitor. This structure has served an important role in the design of newer beta-secretase inhibitors. (http://www.proteopedia.org/wiki/index.php/1tqf) | ||
==Structure== | |||
Our protein is mostly composed of <scene name='Sandbox16/Mynewscene/1'>alpha helices</scene> (shown in red) and <scene name='Sandbox16/Mynewscene1/1'>beta sheets</scene> (shown in blue) which contain some of the <scene name='Sandbox16/Mynewscene2/1'>hydrophobic regions</scene> (shown in purple). The <scene name='Sandbox16/Mynewscene3/1'>ligand</scene> in the center is highlighted in yellow. | Our protein is mostly composed of <scene name='Sandbox16/Mynewscene/1'>alpha helices</scene> (shown in red) and <scene name='Sandbox16/Mynewscene1/1'>beta sheets</scene> (shown in blue) which contain some of the <scene name='Sandbox16/Mynewscene2/1'>hydrophobic regions</scene> (shown in purple). The <scene name='Sandbox16/Mynewscene3/1'>ligand</scene> in the center is highlighted in yellow. | ||
