Sandbox22: Difference between revisions
No edit summary |
No edit summary |
||
| Line 6: | Line 6: | ||
===Structure==={{STRUCTURE_1v4s| PDB=1v4s | SCENE= }} | ===Structure==={{STRUCTURE_1v4s| PDB=1v4s | SCENE= }} | ||
The glucokinase has 18 <scene name='Sandbox22/Alpha_helices/1'>alpha helices</scene> (unless we counted wrong), 13 <scene name='Sandbox22/Beta_sheets/5'>beta sheets</scene> (this one is for sure), and 3 <scene name='Sandbox22/Ligands/1'>ligands</scene>: a sodium ion, | The glucokinase has 18 <scene name='Sandbox22/Alpha_helices/1'>alpha helices</scene> (unless we counted wrong), 13 <scene name='Sandbox22/Beta_sheets/5'>beta sheets</scene> (this one is for sure), and 3 <scene name='Sandbox22/Ligands/1'>ligands</scene>: a <scene name='Sandbox22/Sodium_ion/1'>sodium ion</scene>, <scene name='Sandbox22/Glc/1'>T2 amino-4-fluoro-5-[(1-methyl-1h-amidazol-2-yl)sulfanyl]-n-(1,3-thiazol-2-yl)benzamide</scene> | ||
amide or MRK in short, and last a sugar (alpha-d-glucose) or simply GLC. | |||
===Reference=== | ===Reference=== | ||
Revision as of 16:47, 4 March 2009
This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks!
Glucokinase
This enzyme facilitates phosphorylation of glucose to glucose-6-phosphate. In humans and most other vertebrates glucokinase is used in teh liver, the pancreas, the gut and brain. It plays an important role in regulating carbohydrate metabolism, triggering shifts in the cell in response to glucose level: glucokinase is a sort of a glucose sensor. It only phosphorylates glucose if its concetnration is high enough. The structure of glucokinase reveals an allosteric site through which small molecules may modulate the kinetic properties of the enzyme; a property that is the basis for using the enzyme when treating type 2 diabetes.
Structure
| |||||||||||||
| 1v4s, resolution 2.30Å (default scene) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | GLC, MRK, NA | ||||||||||||
| Activity: | Hexokinase, with EC number 2.7.1.1 | ||||||||||||
| Related: | 1v4t | ||||||||||||
| |||||||||||||
| |||||||||||||
| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
The glucokinase has 18 alpha helices (unless we counted wrong), 13 beta sheets (this one is for sure), and 3 ligands: a sodium ion, T2 amino-4-fluoro-5-[(1-methyl-1h-amidazol-2-yl)sulfanyl]-n-(1,3-thiazol-2-yl)benzamide amide or MRK in short, and last a sugar (alpha-d-glucose) or simply GLC.
Reference
https://www.proteopedia.org/wiki/index.php/1v4s https://en.wikipedia.org/wiki/Glucokinase
--Tinuke (Abike etc. etc. etc.) Adeyemi and Niva Ran
and Matt Joseph Rozin and Gregory Mark Su (because they're so darn cute.)
