Triosephosphate Isomerase: Difference between revisions
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===TRIOSEPHOSPHATE ISOMERASE (TIM, or TPI)=== | ===TRIOSEPHOSPHATE ISOMERASE (TIM, or TPI)=== | ||
'''Triosephosphate isomerase''' is a key enzyme in the glycolytic pathway, which catalyzes the interconversion of dihydroxyacetone phosphate ([http://en.wikipedia.org/wiki/DHAP DHAP]) and glyceraldehyde-3-phosphate ([http://en.wikipedia.org/wiki/Glycerate_3-phosphate GAP]). The remarkable specificity and catalytic power of the enzyme has inspired intensive studies using structural biology, biophysics, and computer simulations. TIM is a perfect enzyme in the sense that its kcat/Km value is in the diffusion-limited range, and because catalytic efficiency is not improved by changes to the chemical composition of the solvent, or by changes to the amino acid sequence of the enzyme. | '''Triosephosphate isomerase''' is a key enzyme in the glycolytic pathway, which catalyzes the interconversion of dihydroxyacetone phosphate ([http://en.wikipedia.org/wiki/DHAP DHAP]) and glyceraldehyde-3-phosphate ([http://en.wikipedia.org/wiki/Glycerate_3-phosphate GAP]). The remarkable specificity and catalytic power of the enzyme has inspired intensive studies using structural biology, biophysics, and computer simulations. TIM is a [http://en.wikipedia.org/wiki/Catalytically_perfect_enzyme catalytically perfect enzyme] in the sense that its kcat/Km value is in the diffusion-limited range, and because catalytic efficiency is not improved by changes to the chemical composition of the solvent, or by changes to the amino acid sequence of the enzyme. | ||
'''Active site features''' | '''Active site features''' | ||
