Factor IX: Difference between revisions
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<applet load='1lbg' size=' | <applet load='1lbg' size='380' frame='true' align='right' scene='Factor_IX/Ixstructure/2' /> | ||
'''Factor IX''' (plasma thromboplastin component, Christmas factor, or hemophilia B factor) is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase. A [[pro-peptide]] functions as a recognition element for a vitamin K-dependent carboxylase (γ-glutamyl carboxylase) which modifies 12 glutamic acid residues to gamma-carboxyglutamyl ( | '''Factor IX''' (plasma thromboplastin component, Christmas factor, or hemophilia B factor) is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase. A [[pro-peptide]] functions as a recognition element for a vitamin K-dependent carboxylase (γ-glutamyl carboxylase) which modifies 12 glutamic acid residues to gamma-carboxyglutamyl ( | ||
<scene name='Factor_IX/Ixstructure_residue/1'>Gla</scene>) residues. These residues are required for the association with the anionic phospholipid surface through Ca2+-dependent binding. The | <scene name='Factor_IX/Ixstructure_residue/1'>Gla</scene>) residues. These residues are required for the association with the anionic phospholipid surface through Ca2+-dependent binding. The | ||
