Factor IX: Difference between revisions
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These mutations identified that residues 495-513 in the carboxylase act as an internal propeptide binding site (7). | These mutations identified that residues 495-513 in the carboxylase act as an internal propeptide binding site (7). | ||
[[Image:8707a900.gif|frame|left|Vitamin K functions in the conversion of glutamic acid (Glu) in gamma-carboxyglutamate (Gla) | [[Image:8707a900.gif|frame|left|Vitamin K functions in the conversion of glutamic acid (Glu) in gamma-carboxyglutamate (Gla) | ||
http://www.natuurlijkerwijs.com/english/ ]] | http://www.natuurlijkerwijs.com/english/ ]] | ||
Step 1: Vitamin K is in its active hydroquinone form: In this reaction a proton (H+ ion) is removed from the glutamic acid in an oxygen (O2) consuming reaction. This reaction leads to a carbon ion aring on the glutamic acid molecule. | |||
Step 2: The glutamic acid carbon ion reacts with CO2 forming gamma-carboxyglutamate. | |||
Step 3 and 4: Active vitamin K in the hydroquinone form is regenerated in two reaction step. | |||
