Factor IX: Difference between revisions

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[[Image:Bc2535756002B.jpeg |frame|right|''The Gla domain of factors IX and X. A, the numbering at the top refers to sequences of bovine (b) factors IX and X, and the numbering at the bottom refers to sequences of human (h) factors IX and X. Gla residues are represented by and colored in red. The black and red arrows above the residues indicate the coordinating Ca2+ and Mg2+ ions, respectively. The yellow columns represent the putative sites on the membrane for the insertion of hydrophobic residues.'']]

The Gla domain is situated at the N-terminus of coagulation factor IX, and is evolutionary conserved in other vitamin K dependent proteins such as factor VII, X, and prothrombin. A Gla domain is made up of 10-13 of γ-carboxyglutamic acid residues and requires both Ca2+ and Mg2+ ions for membrane association and stabilization of its active three dimensional conformation (2-4).

The Gla domain is situated at the N-terminus of coagulation factor IX, and is [[evolutionary conserved]] in other vitamin K dependent proteins such as factor VII, X, and prothrombin. A Gla domain is made up of 10-13 of γ-carboxyglutamic acid residues and requires both Ca2+ and Mg2+ ions for membrane association and stabilization of its active three dimensional conformation (2-4).

Factor IX: Difference between revisions

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 <applet load='1lbg' size='400' frame='true' align='left' scene='Factor_IX/Gladomain/1' />
-[[Image:Bc2535756002B.jpeg |frame|right|''The Gla domain of factors IX and X. A, the numbering at the top refers to sequences of bovine (b) factors IX and X, and the numbering at the bottom refers to sequences of human (h) factors IX and X. Gla residues are represented by  and colored in red. The black and red arrows above the residues indicate the coordinating Ca2+ and Mg2+ ions, respectively. The yellow columns represent the putative sites on the membrane for the insertion of hydrophobic residues.'']]
-The Gla domain is situated at the N-terminus of coagulation factor IX, and is evolutionary conserved in other vitamin K dependent proteins such as factor VII, X, and prothrombin. A Gla domain is made up of 10-13 of γ-carboxyglutamic acid residues and requires both Ca2+ and Mg2+ ions for membrane association and stabilization of its active three dimensional conformation (2-4).
+The Gla domain is situated at the N-terminus of coagulation factor IX, and is [[evolutionary conserved]] in other vitamin K dependent proteins such as factor VII, X, and prothrombin. A Gla domain is made up of 10-13 of γ-carboxyglutamic acid residues and requires both Ca2+ and Mg2+ ions for membrane association and stabilization of its active three dimensional conformation (2-4).