Factor IX: Difference between revisions

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	To further probe into the structure of FIX Gla domain, conformation-specific anti-Factor IX antibodies were utilized. Using an anti-Factor IX antibody, 10C12, which is then reformatted into a F(ab')2 form (two Fab fragments connected by a leucine zipper). This antibody is a calcium specific antibody for factor IX and provides information on the inhibition of membrane binding. by this conformation-specific antibody. The antibody interacts with the loop (Leu-6, Phe-9, and Val-10) of the -carboxyglutamic acids residues bound to calcium ions in the Gla domain.		To further probe into the structure of FIX Gla domain, [[conformation-specific anti-Factor IX antibodies]] were utilized. Using an anti-Factor IX antibody, 10C12, which is then reformatted into a F(ab')2 form (two Fab fragments connected by a leucine zipper). This antibody is a calcium specific antibody for factor IX and provides information on the inhibition of membrane binding. by this conformation-specific antibody. The antibody interacts with the loop (Leu-6, Phe-9, and Val-10) of the -carboxyglutamic acids residues bound to calcium ions in the Gla domain.

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