User:Jaime Prilusky/SequenceToStructure: Difference between revisions

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Jaime Prilusky (talk | contribs)
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Jaime Prilusky (talk | contribs)
ConfirmAccount, Editor, Mutation, Next, Print3D, Tester, any2jmol, Bureaucrats, Interface administrators, journal, print3d, Administrators, tester
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<applet load='T0498.pdb' size='300' frame='true' align='right' caption='T0498' scene='User:Jaime_Prilusky/SequenceToStructure/T0498/1' />
<applet load='T0499.pdb' size='300' frame='true' align='right' caption='T0499' scene='User:Jaime_Prilusky/SequenceToStructure/T0499/1' />
<applet load='T0499.pdb' size='300' frame='true' align='right' caption='T0499' scene='User:Jaime_Prilusky/SequenceToStructure/T0499/1' />


== A one-way street ==
A very basic axiom in Structural Bioinformatics states that a protein sequence has all the required information to fold and become a spatial structure. This sounds reasonable as long as a the same protein sequence, with no extra help, always assumes the same three dimensional configuration when folding. No external guidance. No errors. The sequence simply ''knows'' it's final destination.
A very basic axiom in Structural Bioinformatics states that a protein sequence has all the required information to fold and become a spatial structure. This sounds reasonable as long as a the same protein sequence, with no extra help, always assumes the same three dimensional configuration when folding. No external guidance. No errors. The sequence simply ''knows'' it's final destination.


In summary: multiple copies of the same protein sequence will always fold into the same 3D structure. Different protein sequences will, of course, fold into different spatial conformations.
In summary: multiple copies of the same protein sequence will always fold into the same 3D structure. Different protein sequences will, of course, fold into different spatial conformations.
This sounds like a clear one-way street example: from any given protein sequence you can obtain one, and only one structure.
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