Site: Difference between revisions

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A ''site'', or ''functional site'', is region in a three-dimensional protein structure that performs a function. The site is composed of a cluster of [[Standard_Residues|amino acids]], but non-amino-acid components may also be required for function (such as metal ions). Typical sites could be catalytic sites that bind substrates in enzymes, regulatory sites that bind regulatory factors, sites that bind non-protein entities such as metal ions, and sites that bind nucleic acids or other proteins. Functional sites are usually [[Conservation, Evolutionary|evolutionarily conserved]], but are sometimes [[Conservation, Evolutionary#Locating_Variable_Patches|evolutionarily hypervariable]].

==Sites Green Links==

The '''Sites''' green links in ''Proteopedia'' highlight the residues (as sticks) that make up functional sites as defined in the PDB file being displayed. You may have to zoom in to see them clearly. For example, at the [[Main Page]] (or if not there, at [[1eve]]), below the molecule, are green links to highlight a catalytic site, and an inhibitor binding site. These two sites were abbreviated in the [[atomic coordinate file]] as CAT and IHB, respectively. Clicking on the green links displays the full name of the site immediately below the molecule.

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+A ''site'', or ''functional site'', is region in a three-dimensional protein structure that performs a function. The site is composed of a cluster of [[Standard_Residues|amino acids]], but non-amino-acid components may also be required for function (such as metal ions). Typical sites could be catalytic sites that bind substrates in enzymes, regulatory sites that bind regulatory factors, sites that bind non-protein entities such as metal ions, and sites that bind nucleic acids or other proteins. Functional sites are usually [[Conservation, Evolutionary|evolutionarily conserved]], but are sometimes [[Conservation, Evolutionary#Locating_Variable_Patches|evolutionarily hypervariable]].
 ==Sites Green Links==
 The '''Sites''' green links in ''Proteopedia'' highlight the residues (as sticks) that make up functional sites as defined in the PDB file being displayed. You may have to zoom in to see them clearly. For example, at the [[Main Page]] (or if not there, at [[1eve]]), below the molecule, are green links to highlight a catalytic site, and an inhibitor binding site. These two sites were abbreviated in the [[atomic coordinate file]] as CAT and IHB, respectively. Clicking on the green links displays the full name of the site immediately below the molecule.