Epitopes: Difference between revisions
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Antibody epitopes can be made up of '''discontinuous''' portions of a protein antigen's sequence, or of a continuous portion. In contrast, T cell epitopes always represent a '''continuous''' fragment of the sequence of a protein antigen. | Antibody epitopes can be made up of '''discontinuous''' portions of a protein antigen's sequence, or of a continuous portion. In contrast, T cell epitopes always represent a '''continuous''' fragment of the sequence of a protein antigen. | ||
Antibody epitopes can occur on the surfaces of | Antibody epitopes can occur on the surfaces of '''native''' folded proteins, or equally well on '''denatured''' conformations of proteins. Peptides are typically too short to have a well-defined fold, yet sometimes can simulate the epitope, binding to antibodies. T cell epitopes are always peptide fragments, and hence, represent a denatured (unfolded) form of the native protein. | ||
==Epitope Prediction Servers== | ==Epitope Prediction Servers== | ||
