2k9r: Difference between revisions

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===Enhancing the activity of insulin by stereospecific unfolding===
===Enhancing the activity of insulin by stereospecific unfolding===


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{{ABSTRACT_PUBMED_19321436}}


==Disease==
==Disease==
Known disease associated with this structure: Diabetes mellitus, rare form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]], Hyperproinsulinemia, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]], MODY, one form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]]
Known disease associated with this structure: Hyperproinsulinemia, familial, with or without diabetes OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]]


==About this Structure==
==About this Structure==
2K9R is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9R OCA].  
2K9R is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9R OCA].  
==Reference==
<ref group="xtra">PMID:19321436</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hu, S Q.]]
[[Category: Hu, S Q.]]
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[[Category: Secreted]]
[[Category: Secreted]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 20 07:52:17 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun  3 09:32:58 2009''

Revision as of 06:32, 3 June 2009

File:2k9r.png

Template:STRUCTURE 2k9r

Enhancing the activity of insulin by stereospecific unfolding

Template:ABSTRACT PUBMED 19321436

Disease

Known disease associated with this structure: Hyperproinsulinemia, familial, with or without diabetes OMIM:[176730]

About this Structure

2K9R is a 2 chains structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. Hua QX, Xu B, Huang K, Hu SQ, Nakagawa S, Jia W, Wang S, Whittaker J, Katsoyannis PG, Weiss MA. Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins. J Biol Chem. 2009 May 22;284(21):14586-96. Epub 2009 Mar 25. PMID:19321436 doi:10.1074/jbc.M900085200

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