2boo: Difference between revisions
New page: left|200px<br /> <applet load="2boo" size="450" color="white" frame="true" align="right" spinBox="true" caption="2boo, resolution 1.80Å" /> '''THE CRYSTAL STRUCTU... |
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==About this Structure== | ==About this Structure== | ||
2BOO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]] with NO3 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BOO OCA]]. | 2BOO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]] with NO3 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Hydrolase Hydrolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BOO OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: uracil-dna glycosylase]] | [[Category: uracil-dna glycosylase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:23:37 2007'' | ||
Revision as of 06:18, 30 October 2007
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THE CRYSTAL STRUCTURE OF URACIL-DNA N-GLYCOSYLASE (UNG) FROM DEINOCOCCUS RADIODURANS.
Overview
Uracil-DNA glycosylases are DNA-repair enzymes that catalyse the removal, of promutagenic uracil from single- and double-stranded DNA, thereby, initiating the base-excision repair (BER) pathway. Uracil in DNA can occur, by mis-incorporation of dUMP in place of dTMP during DNA synthesis or by, deamination of cytosine, resulting in U-A or U-G mispairs. The, radiation-resistant bacterium Deinococcus radiodurans has an elevated, number of uracil-DNA glycosylases compared with most other organisms. The, crystal structure of dr0689 (uracil-DNA N-glycosylase), which has been, shown to be the major contributor to the removal of mis-incorporated, uracil bases in crude cell extracts of D. radiodurans, is reported.
About this Structure
2BOO is a [Single protein] structure of sequence from [Deinococcus radiodurans] with NO3 as [ligand]. Active as [Hydrolase], with EC number [3.2.2.3]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans., Leiros I, Moe E, Smalas AO, McSweeney S, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1049-56. Epub 2005, Jul 20. PMID:16041069
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