Nitric Oxide Synthase: Difference between revisions
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==== Substrate binding ==== | ==== Substrate binding ==== | ||
The active site is highly conserved in the different NOS species. Thus it is possible to discuss substrate binding i general terms. The NOS enzyme binds its substrate by hydrogen bindings both to the guanidino[http://en.wikipedia.org/wiki/Guanidino] end and the amino acid end | The active site is highly conserved in the different NOS species. Thus it is possible to discuss substrate binding i general terms. The NOS enzyme binds its substrate (L-argignin) in the distal pocket by hydrogen bindings both to the guanidino[http://en.wikipedia.org/wiki/Guanidino] end and the amino acid end. <scene name='Nitric_oxide_synthase/Substratebinding_test/1'>Substrate in the catalytic site</scene> is shown in green with the heme and H<sub>4</sub>B shown. NOS binds its substrate by coordinating CO to the heme at the site occupied by oxygen<ref>PMID:9376373 </ref>. The binding of L-arginin leads to a 2-step transformation | ||
<scene name='Nitric_oxide_synthase/Substratebinding_test/1'>Substrate in catalytic site</scene> is shown in green with the heme and H<sub>4</sub>B shown. | |||
binds its substrate | |||
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