Nitric Oxide Synthase: Difference between revisions
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==== General Structure ==== | ==== General Structure ==== | ||
The oxygenase domain can be divided into three subdomains. Firstly, the substrate-binding subdomain, which is crescent in shape, binds the substrate in an interior pocket of the crescent. The Heme group is located between the tips of the crescent shape, thus closing the pocket in which the substrate is located. Secondly | The oxygenase domain can be divided into three subdomains. Firstly, the substrate-binding subdomain, which is crescent in shape, binds the substrate in an interior pocket of the crescent. The Heme group is located between the tips of the crescent shape, thus closing the pocket in which the substrate is located. Secondly the H<sub>4</sub>B binding subdomain serves as a cap for the cavity created by the substrate binding domains crescent shape. Thirdly there is a subdomain with two helical bundles making up a hydrophobic core, however this subdomain is not thought to take part in the catalytic activity of the enzyme. | ||
==== Substrate binding ==== | ==== Substrate binding ==== | ||
