Sandbox 12345: Difference between revisions
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==Acetylcholinesterase in complex with tacrine== | ==Acetylcholinesterase in complex with tacrine== | ||
<applet load='1acj' size='300' frame='true' align='right' caption='Insert caption here' /> | |||
In the crystal structure of Torpedo californica [[acetylcholinesterase]] | In the crystal structure of Torpedo californica [[acetylcholinesterase]] | ||
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the DECA complex it lies parallel to the surface of the gorge; in the | the DECA complex it lies parallel to the surface of the gorge; in the | ||
other two complexes it is positioned to make contact with the bound | other two complexes it is positioned to make contact with the bound | ||
ligand. This close interaction was confirmed by photoaffinity labeling | ligand. This close interaction was confirmed <ref>PMID:8415649</ref> by photoaffinity labeling | ||
by a 3H-labeled photosensitive probe, which labeled, predominantly, | by a 3H-labeled photosensitive probe, which labeled, predominantly, | ||
F330 within the active site. Labeling of W279 was also observed. One | F330 within the active site. Labeling of W279 was also observed. One | ||
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subsite of the active site and W279 to the "peripheral" anionic site. | subsite of the active site and W279 to the "peripheral" anionic site. | ||
<references/> | |||
