2cn4: Difference between revisions
New page: left|200px<br /> <applet load="2cn4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cn4, resolution 2.30Å" /> '''THE CRYSTAL STRUCTU... |
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==About this Structure== | ==About this Structure== | ||
2CN4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]] with PO4 and HEM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CN4 OCA]]. | 2CN4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]] with PO4 and HEM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: HEM. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CN4 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: transport protein]] | [[Category: transport protein]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:25:05 2007'' | ||
Revision as of 06:20, 30 October 2007
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THE CRYSTAL STRUCTURE OF THE SECRETED DIMERIC FORM OF THE HEMOPHORE HASA REVEALS A DOMAIN SWAPPING WITH AN EXCHANGED HEME LIGAND
Overview
To satisfy their iron needs, several Gram-negative bacteria use a heme, uptake system involving an extracellular heme-binding protein called, hemophore. The function of the hemophore is to acquire free or, hemoprotein-bound heme and to transfer it to HasR, its specific outer, membrane receptor, by protein-protein interaction. The hemophore HasA, secreted by Serratia marcescens, an opportunistic pathogen, was the first, to be identified and is now very well characterized. HasA is a monomer, that binds one b heme with strong affinity. The heme in HasA is highly, exposed to solvent and coordinated by an unusual pair of ligands, a, histidine and a tyrosine. Here, we report the identification, the, characterization and the X-ray structure of a dimeric form of HasA from S., marcescens: DHasA. ... [(full description)]
About this Structure
2CN4 is a [Single protein] structure of sequence from [Serratia marcescens] with PO4 and HEM as [ligands]. Structure known Active Site: HEM. Full crystallographic information is available from [OCA].
Reference
The crystal structure of the secreted dimeric form of the hemophore HasA reveals a domain swapping with an exchanged heme ligand., Czjzek M, Letoffe S, Wandersman C, Delepierre M, Lecroisey A, Izadi-Pruneyre N, J Mol Biol. 2007 Jan 26;365(4):1176-86. Epub 2006 Oct 25. PMID:17113104
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