3e2t: Difference between revisions

Line 37:

The <scene name='User:Michael_Skovbo_Windahl/sandbox/3e2t_iron_coordination/3'>iron is coordinated</scene> by 2 histidines, one glutamate and one imidazole from the solvent.

This coordination is called the 2-histidine-1-glutamate facial triad iron coordination and is seen in many mononuclear non-heme iron(II)enzymes<ref>PMID: 15739104</ref>. In this structure Glu317 coordinates the iron in a partial bidentate manner. The more common <scene name='User:Michael_Skovbo_Windahl/sandbox/1mlw_iron_coordination/3'>octahedral iron coordination</scene> (the resting state) for the 2-His-1-Glu iron coordination is seen in the structure of human TPH1 [[1mlw]].

This coordination is called the 2-histidine-1-glutamate facial triad iron coordination and is seen in many mononuclear non-heme iron(II)enzymes<ref>PMID: 15739104</ref>. In this structure Glu317 coordinates the iron in a partial bidentate manner. The more common <scene name='User:Michael_Skovbo_Windahl/sandbox/1mlw_iron_coordination/3'>octahedral iron coordination</scene> (the resting state) for the 2-His-1-Glu iron coordination is seen in the structure of human TPH1 ([[1mlw]]).

== Imidazole binding ==

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 <applet load='3e2t' size='400' frame='true' align='right' caption='catalytic domain of TPH1' scene='3e2t/3e2t_overall/2' />
 The <scene name='User:Michael_Skovbo_Windahl/sandbox/3e2t_iron_coordination/3'>iron is coordinated</scene> by 2 histidines, one glutamate and one imidazole from the solvent.
-This coordination is called the 2-histidine-1-glutamate facial triad iron coordination and is seen in many mononuclear non-heme iron(II)enzymes<ref>PMID: 15739104</ref>. In this structure Glu317 coordinates the iron in a partial bidentate manner. The more common <scene name='User:Michael_Skovbo_Windahl/sandbox/1mlw_iron_coordination/3'>octahedral iron coordination</scene> (the resting state) for the 2-His-1-Glu iron coordination is seen in the structure of human TPH1 [[1mlw]].
+This coordination is called the 2-histidine-1-glutamate facial triad iron coordination and is seen in many mononuclear non-heme iron(II)enzymes<ref>PMID: 15739104</ref>. In this structure Glu317 coordinates the iron in a partial bidentate manner. The more common <scene name='User:Michael_Skovbo_Windahl/sandbox/1mlw_iron_coordination/3'>octahedral iron coordination</scene> (the resting state) for the 2-His-1-Glu iron coordination is seen in the structure of human TPH1 ([[1mlw]]).
 == Imidazole binding ==