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'''Unreleased structure'''
{{Seed}}
[[Image:3ee0.jpg|left|200px]]


The entry 3ee0 is ON HOLD until Paper Publication
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{{STRUCTURE_3ee0|  PDB=3ee0  |  SCENE=  }}


Authors: Gandhi, P.S., Page, M.J., Chen, Z., Bush-Pelc, L., Di Cera, E.
===Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1))===


Description: Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1))


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 17 13:41:17 2008''
==Disease==
Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]]
 
==About this Structure==
3EE0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE0 OCA].
 
==Reference==
<ref group="xtra">PMID:15252033</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Thrombin]]
[[Category: Bush-Pelc, L.]]
[[Category: Cera, E Di.]]
[[Category: Chen, Z.]]
[[Category: Gandhi, P S.]]
[[Category: Page, M J.]]
[[Category: Acute phase]]
[[Category: Blood coagulation]]
[[Category: Calcium]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Disease mutation]]
[[Category: Gamma-carboxyglutamic acid]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Kringle]]
[[Category: Pharmaceutical]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Secreted]]
[[Category: Serine protease]]
[[Category: Zymogen]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  8 12:40:45 2009''

Revision as of 09:40, 8 July 2009

File:3ee0.jpg

Template:STRUCTURE 3ee0

Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1))

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

3EE0 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:15252033 doi:https://dx.doi.org/10.1074/jbc.M407272200

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