C-Myc: Difference between revisions
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{{STRUCTURE_c-Myc PDB=2a93 | SCENE= }} | {{STRUCTURE_c-Myc PDB=2a93 | SCENE= }} | ||
The c-Myc onco-protein is a transcription factor involved in the regulation of the cell cycle. C-Myc belongs to the Myc family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a b-HLH-LZ (basic helix-loop-helix-leucine zipper) protein that must form a heterodimer with another b-HLH-LZ protein, Max, in order to bind DNA and activate transcription. | |||
Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | |||
