C-Myc: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
<applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/> | <nowiki>Insert non-formatted text here</nowiki><applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/> | ||
The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription]. | The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription]. | ||
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | ||
== References == | |||
---- | |||
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. Molecular and Cellular Biology, volume 19, number 1. | |||
Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. Cell, 112:193-205. | |||
