Nitric Oxide Synthase: Difference between revisions

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 == The reaction of NOS ==
-As previously described NOS is an enzyme split in to different domains; the N-terminal oxygenase domain and the C-terminal reductase domain.
+As previously described NOS is an enzyme consisting of two domains; the N-terminal oxygenase domain and the C-terminal reductase domain.
-The oxygenase domain is where the production of NO takes place, whereas the reductase domain provides the electrons necessary to drive the reaction in the oxygenase domain.
+The NO production takes plase in the oxygenase domain, whereas the reductase domain provides the electrons necessary to drive the reaction in the oxygenase domain.
 The reaction is:
 [[image:Makroprojekt-chemdraw-1-.gif|frame|center]]
-The amino acid L-Arginine is turned in to L-Citrulline and NO. The reaction is driven by the oxidation of NADPH to NADP<sup>+</sup>, which in total yields 5 electrons for the reaction.
+Teh reaction occurs in two steps. In the first step L-arginine is turned in to N-hydroxy-arginine. In the second step L-citrulline and NO are formed. The reaction utilizes 2 O<sub>2</sub> and 3 electrons from 3/2 NADPH.
-The reaction above therefore takes both the oxygenase and the reductase domain into account.
 == The Oxygenase domain of NOS ==

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